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Introduction  PFAPA syndrome , which stands for Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis, is a rare autoinflammatory condition that primarily affects children. It is characterized by recurrent episodes of fever, painful mouth sores (aphthous stomatitis), sore throat (pharyngitis), and swollen lymph nodes (adenitis). These episodes occur at regular intervals, making PFAPA syndrome unique and distinct from other diseases that cause similar symptoms but without predictable patterns. In this article, we will delve into the causes, symptoms, diagnosis, and treatment options for PFAPA syndrome, and discuss why early detection and proper treatment are crucial for managing this condition. What is PFAPA Syndrome? PFAPA syndrome is an autoinflammatory disorder that typically starts in early childhood, most commonly between the ages of 2 and 5 years. Children with PFAPA experience recurring fever episodes, usually occurring at regular intervals (e.g., every 3 to 6 weeks)...